Effects of COVID-19 on pregnancy and delivery outcome: systematic review with meta-analysis
- Author:
Nasantogtokh E
1
;
Baljinnyam B
1
;
Enkhmaa D
1
;
Altantuya Sh
1
Author Information
1. National Center for Maternal Child Health
- Publication Type:Journal Article
- Keywords:
pregnancy;
COVID-19;
stillbirth;
premature birth
- From:Mongolian Journal of Obstetrics, Gynaecology and Pediatrics
2021;30(2):2180-2185
- CountryMongolia
- Language:Mongolian
-
Abstract:
Effects of COVID-19 on pregnancy and delivery outcome: systematic review with meta-analysis:Introduction: The impact of Coronavirus infection disease (COVID-19) on during pregnancy, maternal outcome, and neonatal health is unclear. We aimed to measure about effect of Coronavirus infection to pregnancy, maternal outcome, and newborn health in systematic review with meta-analysis.
Materials and methods: The systematic review and meta-analysis conducted PRISMA guidelines, recommended from Cochrane, based on database of studies and a hypothesis to determine the impact of COVID-19 on pregnancy, maternal, and neonatal outcome. We searched for eligible studies of databases from December 2019 to April 2021. Our dependent variables were preeclampsia, preterm birth and stillbirth. Independent variables were infection of COVID during pregnancy, and outcomes. We measured for primary outcome that are preeclampsia, preterm birth, and secondary stillbirth. The meta-analysis evaluated the quality of the observational study (Newcastle – Ottawa Scale) and included the results. Statistical analysis was performed using Rev Man 5.0 software. The ratio (OR) in meta-analysis was calculated using a meta-regression model (Random effect meta-analysis). The mean difference was measured and weighed 95.0% confidence interval.
Results: We included 46 studies involving 459,789 participants. Coronavirus infection maybe associated with increase the risks of preeclampsia in pregnancy (B: 1.21, 95.0% CI: 1.01 - 1.25), premature birth (B: 1.91, 95.0% CI: 1.62–2.15), stillbirth (B: 2.2, 95.0% CI: 2.12–2.31.
Conclusions: Coronavirus infection increases the risk of preeclampsia, premature birth and stillbirth. Furthermore, the studies are needed to collect more robust data to validate or substantiate these findings, better understand the impact of COVID on pregnancy in experiment, intervention, and cohort studies with Meta-Analysis.
- Full text:2025111309572450348Судалгаа 3, Э.Насантогтох..docx
