Four Year Trend of Carbapenem-Resistance in Newly Opened ICUs of a University-Affiliated Hospital of South Korea.
10.4046/trd.2012.72.4.360
- Author:
Bo Min KIM
1
;
Eun Ju JEON
;
Ju Young JANG
;
Jin Won CHUNG
;
Jihoon PARK
;
Jae Chol CHOI
;
Jong Wook SHIN
;
In Won PARK
;
Byoung Whui CHOI
;
Jae Yeol KIM
Author Information
1. Division of Pulmonary and Allergy, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. jykimmd@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Carbapenems;
Drug Resistance, Bacterial;
Intensive Care Units
- MeSH:
Acinetobacter baumannii;
APACHE;
Bacteria;
Carbapenems;
Catheters;
Drug Resistance, Bacterial;
Enterobacteriaceae;
Humans;
Intensive Care Units;
Pseudomonas aeruginosa;
Republic of Korea;
Suction
- From:Tuberculosis and Respiratory Diseases
2012;72(4):360-366
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Carbapenem-resistance is rapidly evolving among the pathogenic microbes in intensive care units (ICUs). This study aimed to determine annual trend of carbapenem-resistance in the ICU for 4 years, since the opening of a university-affiliated hospital in South Korea. METHODS: From 2005 to 2008, microbial samples from consecutive 6,772 patients were screened in the ICU. Three hundred and ninety-seven patients (5.9%) and their first isolates of carbapenem-resistant pathogens were analyzed. RESULTS: The percentage of patients infected with carbapenem-resistant organisms increased constantly during the initial three years (2.3% in 2005, 6.2% in 2006, 7.8% in 2007), then it declined to 6.5% in 2008. Acute Physiology and Chronic Health Evaluation (APACHE) III score at admission was 58.0+/-23.5, the median length of the ICU stay was 37 days, and the mortality rate was 37.5%. The sampling sites were endotracheal suction (67%), catheterized urine (17%), wound (6%) and others (10%). Bacteria with carbapenem-resistance were Pseudomonas aeruginosa (247 isolates, 62%), Acinetobacter baumannii (117 isolates, 30%), Enterobacteriaceae (12 isolates, 3%), and others (21, 5%). Of note, peak isolation of carbapenem-resistant microorganisms in medical ICU was followed by the same epidemic at surgical ICU. CONCLUSION: Taken together, carbapenem-resistant pathogens are of growing concern in the ICU.
