Research progress on ionizing radiation exposure and thyroid cancer
10.19485/j.cnki.issn2096-5087.2025.05.008
- Author:
JIANG Xinyue
;
LIU Jienan
;
GAO Meiling
;
WANG Yuchao
;
HONG Yina
;
YAN Jianbo
- Publication Type:Journal Article
- Keywords:
ionizing radiation exposure;
thyroid cancer;
dose-response relationship;
molecular mechanism
- From:
Journal of Preventive Medicine
2025;37(5):471-476,480
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid cancer is caused by multiple factors, including genetics, environment, metabolism, and the immune microenvironment, among which ionizing radiation exposure is an important risk factor for thyroid cancer. As one of the most sensitive target organs of ionizing radiation, the thyroid gland may have different risks of thyroid cancer caused by different types of ionizing radiation exposures, such as medical exposure, occupational exposure, and emergency exposure. The sensitivity of children and adolescents are higher than that of adults. The dose-response relationship still needs to be further explored. The molecular mechanism between ionizing radiation and the increased risk of thyroid cancer is complex, which may involve DNA damage and repair abnormalities, gene mutations, non-coding RNA regulation, DNA methylation, cell cycle regulation imbalance, and immune microenvironment changes. This article reviews the risk and molecular mechanisms associated with different types of ionizing radiation exposure in thyroid cancer, based on literature retrieved from CNKI and PubMed databases. It aims to provide a theoretical basis for the early monitoring, prevention, and intervention of thyroid cancer related to ionizing radiation exposure.
- Full text:2025110410573166312电离辐射暴露与甲状腺癌的研究进展.pdf
