Association between micronutrients and irritable bowel syndrome: a Mendelian randomization study
10.19485/j.cnki.issn2096-5087.2025.04.012
- Author:
ZHANG Yuanyuan
;
XU Hexiang
;
LI Ming
- Publication Type:Journal Article
- Keywords:
irritable bowel syndrome;
micronutrient;
Mendelian randomization
- From:
Journal of Preventive Medicine
2025;37(4):378-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the causal association between micronutrients and irritable bowel syndrome (IBS) using a Mendelian randomization (MR) method, so as to provide the evidence for formulating prevention and treatment measures for IBS.
Methods:Genome-wide association studies (GWAS) summary data for 14 micronutrients (copper, selenium, zinc, iron, magnesium, calcium, potassium, folate, vitamin C, vitamin D, vitamin E, vitamin B6, vitamin B12, and carotene) were collected from the MRC Integrative Epidemiology Unit at the University of Bristol GWAS data and the UK Biobank data. GWAS data for IBS were obtained from the FinnGen R10 database. A bidirectional two-sample MR analysis was conducted to assess the causal relationships between micronutrients and IBS, with the inverse-variance weighted method as the primary analytical approach. Heterogeneity among instrumental variables was evaluated using Cochran's Q test. Horizontal pleiotropy was assessed via MR-Egger regression and the MR-PRESSO test. The robustness of the results was examined using leave-one-out and funnel plot.
Results:Forward MR analysis revealed a statistically significant association between vitamin B12 and IBS (OR=1.523, 95%CI: 1.093-2.213), while no significant associations were observed for the other 13 micronutrients (all P>0.05). Reverse MR analysis showed no significant association between IBS and any of the 14 micronutrients (all P>0.05). Sensitivity analyses revealed no evidence of heterogeneity or horizontal pleiotropy among the instrumental variables (all P>0.05). The robustness of the findings was supported by leave-one-out and funnel plot.
Conclusion:Higher vitamin B12 level is associated with an increased risk of IBS, but no reverse causal relationship between vitamin B12 and IBS has been found.
- Full text:2025110311244198918微量营养素与肠易激综合征的孟德尔随机化研究.pdf
