Research Progress on Mechanism of NAD+ Metabolic Remodeling in Occurrence and Development of Glioblastoma Multiforme
10.3971/j.issn.1000-8578.2025.25.0201
- VernacularTitle:NAD+代谢重塑在胶质母细胞瘤发生发展中的作用机制研究进展
- Author:
Jiajia CHE
1
;
Jinyuan DU
1
;
Junhao BAO
1
;
Xiting PAN
1
;
Chengwen WANG
1
;
Chuan XU
1
;
Ying SHI
1
Author Information
1. Department of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
- Publication Type:REVIEWS
- Keywords:
GBM;
NAD+;
Cell metabolism;
Cell proliferation;
Tumor immunity
- From:
Cancer Research on Prevention and Treatment
2025;52(10):861-868
- CountryChina
- Language:Chinese
-
Abstract:
Gliomas, especially high-grade gliomas such as glioblastoma multiforme (GBM), are primary malignant tumors of the central nervous system, characterized by high proliferative capacity, invasiveness, and therapeutic resistance. The development of GBM relies heavily on continuous metabolic reprogramming to adapt to the unique intracranial microenvironment, with nicotinamide adenine dinucleotide (NAD+) metabolic remodeling playing a pivotal role. Dysregulation of NAD+ and its associated metabolic pathways sustains increased intracellular NAD+ levels, which drive the malignant proliferation and invasive potential of GBM, correlating with worsened patient prognosis. This review systematically summarizes the current research landscape of NAD+ metabolic remodeling in GBM, elucidates the mechanisms by which NAD+ contributes to GBM pathogenesis and progression, and explores the clinical potential of NAD+-targeted diagnostic and therapeutic strategies to provide novel insights and directions for the clinical management of GBM.
