Recent Advances of Immune Checkpoint Inhibitors in Treatment of Cervical Cancer
10.3971/j.issn.1000-8578.2025.25.0199
- VernacularTitle:免疫检查点抑制剂在宫颈癌治疗中的研究新进展
- Author:
Haojie QIN
1
;
Zhifan ZUO
2
;
Dan CHEN
2
;
Jia LIU
2
;
Shan JIN
2
;
Yang ZHANG
3
;
Yongpeng WANG
2
Author Information
1. The First Clinical College of Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China;Department of Gynecology, Liaoning Cancer Hospital & Institute/Cancer Hospital of Dalian University of Technology/Cancer Hospital of China Medical University, Shenyang 110042, China.
2. Department of Gynecology, Liaoning Cancer Hospital & Institute/Cancer Hospital of Dalian University of Technology/Cancer Hospital of China Medical University, Shenyang 110042, China.
3. Department of Gynecology, the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China.
- Publication Type:REVIEWS
- Keywords:
Cervical cancer;
Immune checkpoint inhibitor;
Immunity re-challenge
- From:
Cancer Research on Prevention and Treatment
2025;52(10):848-854
- CountryChina
- Language:Chinese
-
Abstract:
As a hot spot in clinical research today, immune checkpoint inhibitor has been recommended by guidelines in the first- and second-line treatments of advanced cervical cancer as immune monotherapy or combination therapy. It has also achieved good efficacy in clinical practice. In locally advanced cervical cancer, immune checkpoint inhibitors have been included in the guidelines for adjuvant therapy, and good tumor regression effects have been achieved in clinical practice. Based on the results of existing trials, immune checkpoint inhibitors have also shown good clinical potential as neoadjuvant therapy. Furthermore, the issue of immunotherapy rechallenge has increasingly captured clinicians’ attention, offering a potential new therapeutic strategy for cervical cancer patients with prior immunotherapy exposure. In this article, the clinical application and research progress of immune checkpoint inhibitors in the treatment of cervical cancer in recent years are summarized to provide valuable ideas and directions for clinical treatment.
