Chikungunya Fever： Recognition， Treatment， Prevention and Control
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0502
- VernacularTitle:基孔肯雅热：识别、治疗与防控
- Author:
Yunfeng SHI
1
;
Benquan WU
1
Author Information
1. Department of MICU // Department of Respiratory and Critical Care Medicine， The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630， China
- Publication Type:Review
- Keywords:
Chikungunya fever;
diagnosis;
differential diagnosis;
treatment;
prevention and control
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(5):730-736
- CountryChina
- Language:Chinese
-
Abstract:
Chikungunya fever （CHIKF） is a mosquito-borne infectious disease caused by Chikungunya virus （CHIKV） infection. The acute phase of CHIKF is mainly characterized by fever， severe polyarthralgia， and rash. Most cases are self-limited， however， atypical manifestations and chronic complications also occur in a minor proportion of cases. High-risk cases are at risk of complicating with severe condition. For these years， the emergence and spread of CHIKF place it as an international public health disease. This article summarizes the current knowledge and advances about CHIKF， with a focus on the diagnosis， differential diagnosis， evaluation， treatment， prevention and control. For individuals with a history of traveling to CHIKF prevalence areas within 12 days， presenting with fever， arthralgia， and rash， combined with laboratory tests such as positive IgM antibody， specific IgG antibody， CHIKV isolation， or viral nucleic acid testing in acute stage， could establish the diagnosis. Differential diagnosis with infection caused by similar viruses such as dengue virus and Zika virus should be considered too. Regarding treatment， there is no specific antiviral drug available currently. Supportive method is the dominating treatment， with non-steroidal anti-inflammatory drugs used to alleviate fever and arthralgia. The core strategy in prevention and control of CHIKF is to interrupt the transmission and eliminate mosquitoes. To meet challenges posed by the spread of CHIKF， the future researches should emphasize on developing specific antiviral drugs， safe and effective vaccines， and convenient and accurate diagnostic means.
