Alleviation of sleep deprivation-induced hyper sleepiness and cognitive impairment by pitolisant, a histamine H3 receptor inverse agonist
10.12206/j.issn.2097-2024.202506008
- VernacularTitle:组胺H3受体反向激动剂替洛利生改善睡眠剥夺诱发的嗜睡和认知功能减退
- Author:
Yan ZHAO
1
;
Jun WEI
1
;
Chaoyu MIAO
1
Author Information
1. Department of Pharmacology, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Originalarticles
- Keywords:
pitolisant;
H3 receptor inverse agonist;
cognitive function;
sleep deprivation;
wakefulness promotion;
pro-cognitive effects
- From:
Journal of Pharmaceutical Practice and Service
2025;43(10):491-495
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of the H3 receptor inverse agonist pitolisant on wakefulness and cognitive behavior in mice subjected to sleep deprivation, and assess its potential wake-promoting and pro-cognitive properties. Methods A mouse model of sleep deprivation was utilized, in which sleep deprivation was performed for 6, 12, and 24 h by an automatic rotating rod system. Pitolisant （20 mg/kg, i.p.） or saline control was administered prior to the end of deprivation. Quantitative wakefulness was monitored by polysomnographic recordings and spontaneous locomotion, spatial learning and memory were assessed through open field test and Morris water maze test, respectively. Results Pitolisant significantly increased wake duration after all sleep deprivation periods, with the most prominent effect observed in the early recovery phase. In the 24 h deprivation model, pitolisant also significantly improved spontaneous locomotor activity and showed a potential enhancement of spatial learning and memory, although the effects did not reach statistical significance. Conclusion Pitolisant not only enhanced wakefulness but also showed partial pro-cognitive effects following sleep loss, which supported its potential application in improving cognitive impairment associated with various sleep disorders.
