Noninvasive diagnosis of anti-mitochondrial antibody-negative primary biliary cholangitis
- VernacularTitle:抗线粒体抗体阴性原发性胆汁性胆管炎的无创诊断
- Author:
Jia ZHOU
1
;
Jingyuan ZHOU
1
;
Yanhang GAO
1
Author Information
- Publication Type:Review
- Keywords: Primary Biliary Cirrhosis; Autoantibodies; Diagnosis; Biomarkers
- From: Journal of Clinical Hepatology 2025;41(9):1896-1901
- CountryChina
- Language:Chinese
- Abstract: Primary biliary cholangitis （PBC） is an autoimmune disease characterized by cholestasis of the intrahepatic bile ducts. Anti-mitochondrial antibody （AMA） is currently the key serum marker for the diagnosis of PBC， and however， there are still 5%—10% of patients with PBC who have undetectable AMA in their serum and need liver biopsy to make a confirmed diagnosis. Noninvasive diagnosis remains a challenge in AMA-negative PBC patients. This article reviews the research advances in specific serum markers other than AMA， summarizes the advantages and disadvantages of these serum markers in the diagnosis of AMA-negative PBC， and analyzes the types of new biomarkers that may be used in the noninvasive diagnosis of patients with AMA-negative PBC， in order to provide new ideas for identifying serum markers with higher sensitivities.
