Discussion on the application of sweet-natured herbs to the treatment of tumor immune-related adverse events based on the theory of "fire and primordial qi incompatibility"
10.3969/j.issn.1006-2157.2025.04.015
- VernacularTitle:基于“火与元气不两立”探讨运用甘药治疗肿瘤免疫相关不良反应
- Author:
Jia WU
1
;
Muyao CUI
2
;
Weidong LI
3
Author Information
1. Guang anmen Hospital, China Academy of Chinese Medical Sciences;China Academy of Chinese Medical Sciences
2. Guang anmen Hospital, China Academy of Chinese Medical Sciences;Beijing University of Chinese Medicine
3. Guang anmen Hospital, China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
fire and primordial qi incompatibility;
immune-related adverse events;
sweet-natured herbs;
tumor therapy;
immune checkpoint inhibitors
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(4):566-572
- CountryChina
- Language:Chinese
-
Abstract:
The theory of "fire and primordial qi incompatibility" was proposed by LI Gao in Clarifying Doubts about Damage from Internal and External Causes, which has important guiding significance for explaining the pathogenesis, prognosis and treatment of immune-related adverse events (irAEs). "Fire" refers to yin fire, a type of deficient fire transformed from the deficiency of the spleen and stomach, reflecting the pathological state of coexisting deficiency and heat patterns in patients with tumor after immune checkpoint inhibitor (ICI) therapy. "Primordial qi" is the most fundamental essence of human life activities and serves as the source of all bodily qi. Based on the theory of "fire and primordial qi incompatibility" and Western medicine research, we found that excessive use of ICIs can damage the spleen and stomach, leading to excessive yin fire. When yin fire becomes excessive, it consumes and injures the primordial qi; when the primordial qi is depleted, it leads to more excessive yin fire and further deficiency of the spleen and stomach, forming a syndrome in which deficiency and excess coexist. Starting from the theory of "fire and primordial qi incompatibility, "combined with our team′s clinical practice and modern pharmacological research, this study explores the application characteristics of sweet-natured herbs for irAEs during ICIs therapy and interval periods, and summarizes the treatment principles, aiming to provide new perspectives and approaches for the prevention and treatment of tumor-related irAEs with traditional Chinese medicine.
- Full text:2025102910354686264Discussion on the application of sweet-natured herbs to the treatment of tumor immune-related adverse events based on the theory of _fire and primordial qi incompatibility_.pdf
