Research progress on targeted recognition mechanism of bacteriophage tail filament protein towards its receptor lipopolysaccharide
10.13200/j.cnki.cjb.004577
- VernacularTitle:噬菌体尾丝蛋白对其受体脂多糖靶向识别机制的研究进展
- Author:
HOU Guanghua
- Publication Type:Journal Article
- Keywords:
Bacteriophages;
Tail filament protein;
Lipopolysaccharide(LPS);
Adsorption;
Receptor
- From:
Chinese Journal of Biologicals
2025;38(10):1258-1262
- CountryChina
- Language:Chinese
-
Abstract:
Bacteriophage is a general term for viruses that can specifically infect microorganisms such as bacteria and fungi.In recent years, with the emergence and popularity of "super resistant bacteria", bacteriophage therapy has once again received attention. Bacteriophage therapy can be used as a biological agent to replace antibiotics in the treatment of bacterial infectious diseases. Lipopolysaccharides(LPSs) are the main components of the outer wall of Gram-negative bacterial cells,which are macromolecular glycolipid consisting of a hydrophobic lipid-like A region and long-chain branched sugars. The LPS O antigen and core oligosaccharide region of Gram-negative bacteria are receptors for the tail filament protein of bacteriophages, and determine their infectivity and host range. This paper summarizes the research progress on the specific binding between bacteriophage tail filament protein and Gram-negative bacterial surface receptor LPS, which mediates bacteriophage adsorption and infection, aiming to provide reference materials for future research on the mechanism of bacteriophage adsorption mediated by LPS and provide a new idea for further studying the interaction mechanism between bacteriophages and host bacteria.
