Current status and advances in the preservation and clinical applications of small incision lenticule extraction-derived lenticules
10.3980/j.issn.1672-5123.2025.11.12
- VernacularTitle:SMILE来源角膜基质透镜的保存及临床应用现状与进展
- Author:
Yuanyuan JIA
1
Author Information
1. Department of Ophthalmology, Tianjin Wuqing District Traditional Chinese Medicine Hospital, Tianjin 301700, China
- Publication Type:Journal Article
- Keywords:
corneal stromal lenticules;
small incision lenticule extraction(SMILE);
preservation methods;
lenticules application
- From:
International Eye Science
2025;25(11):1791-1796
- CountryChina
- Language:Chinese
-
Abstract:
Lenticules are derivative biomaterials obtained from femtosecond laser small incision lenticule extraction(SMILE). Compared to other corneal tissues, they are readily available and exhibit biomechanical properties similar to donor corneas, and have been widely used in clinical treatments. Studies have confirmed that lenticules has a significant effect on various eye diseases such as presbyopia, hyperopia, advanced keratoconus, pellucid marginal degeneration, corneal ulcer and perforation. For cases where immediate lenticule transplantation is unfeasible, establishing effective lenticule preservation systems is critically essential. The current mainstream preservation techniques include cryopreservation combined with media, medium preservation, decellularization preservation, nutritive capsule, and exsiccation, among others. To alleviate the shortage of corneal donors and expand their therapeutic applications in ocular diseases, this review comprehensively summarizes existing preservation technologies for corneal stromal lenticules and synthesizes recent advances in their clinical utilization.
