Research progress of genes in primary open angle glaucoma
10.3980/j.issn.1672-5123.2025.11.08
- VernacularTitle:基因在原发性开角型青光眼中的研究进展
- Author:
Hao HU
1
;
Dadong JIA
1
;
Yiyao WANG
1
;
Liang LIANG
1
Author Information
1. The Second People's Hospital of China Three Gorges University;The Second People's Hospital of Yichang, Yichang 443000, Hubei Province, China
- Publication Type:Journal Article
- Keywords:
primary open angle glaucoma;
mitochondrial dysfunction;
epigenetic regulation;
neuroprotection and regeneration of retinal ganglion cells;
gene editing technology
- From:
International Eye Science
2025;25(11):1764-1770
- CountryChina
- Language:Chinese
-
Abstract:
Primary open angle glaucoma(POAG)is the most common type of glaucoma, with common causes including variations in trabecular tissue and increased venous pressure. POAG has a certain genetic tendency, and POAG with an autosomal dominant inheritance pattern is mainly caused by single gene mutations. Studies have found that the pathogenesis of POAG may be related to key pathogenic genes(MYOC, OPTN, WDR 36), as well as mitochondrial dysfunction, oxidative stress, and epigenetic regulation. At present, the clinical treatment options for POAG mainly include enhancing trabecular meshwork function, inhibiting aqueous humor production, neuroprotection and regeneration of retinal ganglion cells, and applying gene editing technology, all of which have achieved certain results. However, there is no unified research on the relationship between the occurrence of POAG and genes, as well as treatment plans. The article explores new targets and treatment strategies for POAG gene therapy by analyzing the role of genes in the pathogenesis of POAG, aiming to provide reference for clinical treatment of this disease.
