Hematopoietic Engineering: The Current Status and Prospects of In Vitro Erythrocyte Production Technology
10.12290/xhyxzz.2024-0612
- VernacularTitle:血液再生工程：体外红细胞制备技术的研究现状与前景
- Author:
Qianli ZHUO
1
;
Zhaojun ZHANG
2
;
Xiangdong FANG
2
Author Information
1. China National Center for Bioinformation, Beijing 100101, China;Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China;University of Chinese Academy of Sciences, Beijing 100049, China;
2. China National Center for Bioinformation, Beijing 100101, China;Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China;University of Chinese Academy of Sciences, Beijing 100049, China;Beijing Key Laboratory of Genome and Precision Medicine Technologies, Beijing 100101, China;
- Publication Type:Journal Article
- Keywords:
in vitro erythrocyte production;
immortalized red blood cell lines;
enucleation;
culture
- From:
Medical Journal of Peking Union Medical College Hospital
2024;16(5):1179-1184
- CountryChina
- Language:Chinese
-
Abstract:
In vitro erythrocyte manufacturing technology offers a novel solution for transfusion therapy, ensuring sustainable blood supply, reducing dependence on donors, and minimizing the risk of infectious disease transmission. This review summarizes recent advancements in in vitro erythrocyte production, including techniques for generating red blood cells (RBC) from various cell sources, with a focus on the cultivation and development of immortalized erythroid cell lines. The importance of enhancing enucleation efficiency and ensuring the safety of immortalized erythroid cells is emphasized. Additionally, the potential and challenges in clinical translation are discussed, aiming to provide new insights for future sustainable RBC supply and therapeutic applications.
