Advances in research on the potential effects and mechanism of asiaticoside in acute kidney injury
- VernacularTitle:积雪草苷在急性肾损伤中的潜在作用及机制研究进展
- Author:
Yingying ZHOU
1
;
Xinying ZHANG
2
;
Yingying QIAN
3
;
Xiangcheng XIE
3
Author Information
1. The Fourth Clinical Medical College，Zhejiang Chinese Medical University，Hangzhou 310053，China;Dept. of Nephrology，Hangzhou First People’s Hospital Affiliated to Medical School of Westlake University，Hangzhou 310006，China
2. The Fourth Clinical Medical College，Zhejiang Chinese Medical University，Hangzhou 310053，China
3. Dept. of Nephrology，Hangzhou First People’s Hospital Affiliated to Medical School of Westlake University，Hangzhou 310006，China
- Publication Type:Journal Article
- Keywords:
asiaticoside;
acute kidney injury;
oxidative stress;
inflammation;
autophagy;
mechanism of action
- From:
China Pharmacy
2025;36(19):2484-2488
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury （AKI） is a clinical syndrome characterized by a rapid decline in renal function within a short period. Its pathogenesis involves multiple processes， including oxidative stress， inflammatory responses， and programmed cell death， while effective pharmacological interventions remain lacking. Current studies have indicated that asiaticoside， a natural active compound， exhibits nephroprotective potential in the intervention of AKI. The potential mechanisms include the activation of antioxidant signaling such as nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 to mitigate oxidative injury， the regulation of key inflammatory pathways including nuclear factor-κB/NOD-like receptor thermal protein domain associated protein 3， and Janus kinase 2/signal transducer and activator of transcription 3 to suppress inflammation and modulate macrophage polarization； it promotes mitophagy by influencing the expression of apoptosis-related proteins and activating the recombinant sirtuin 1-forkhead box-O3-phosphatase and tensin homolog-induced kinase 1-Parkin pathway so as to maintain cellular homeostasis. As a multi-target natural compound， asiaticoside holds promise for providing novel intervention strategies in the clinical treatment of AKI， yet its efficacy and safety still require validation through large-sample clinical trials.
