Optimization of salt-processing technology for Anemarrhena asphodeloides by Box-Behnken response surface methodology versus GA-BP neural network
- VernacularTitle:Box-Behnken响应面法对比GA-BP神经网络优化知母盐炙工艺
- Author:
Luoxing PAN
1
;
Yiman ZHAO
2
;
Hui YUAN
2
;
Zehua LI
2
;
Dongsheng XUE
3
;
Qing ZHAO
1
Author Information
1. Key Laboratory of Collaborative Innovation in the Industrialization Process of Traditional Chinese Medicine Resources of Hebei Provincial Administration of Traditional Chinese Medicine，College of Traditional Chinese Medicine，Hebei University，Hebei Baoding 071000，China
2. Hebei Baihe Health Pharmaceutical Co.，Ltd.，Hebei Baoding 071299，China
3. Baoding Market Supervision Administration，Hebei Baoding 071023，China
- Publication Type:Journal Article
- Keywords:
Anemarrhena asphodeloides;
salt-processing
- From:
China Pharmacy
2025;36(19):2399-2403
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To optimize the salt-processing technology for Anemarrhena asphodeloides. METHODS Taking soaking time， stir-frying temperature， and stir-frying time as factors， Box-Behnken response surface methodology was employed to optimize the salt-processing technology of A. asphodeloides using the contents of mangiferin， neomangiferin， isomangiferin， timosaponin BⅡ， timosaponin AⅢ， timosaponin BⅢ， total flavonoids， and total saponins as evaluation indicators. The entropy weight method was applied to determine the weight of each indicator and calculate the comprehensive score. Based on the 17 sets of Box-Behnken response surface methodology results， a genetic algorithm （GA）-back propagation （BP） neural network was used to further optimize the salt-processing technology， with soaking time， stir-frying temperature， and stir-frying time as input layers and the comprehensive score as the output layer. The salt-processing parameters obtained from the two methods were validated and compared to determine the optimal salt-processing technology for A. asphodeloides. RESULTS The optimal salt-processing conditions obtained via the Box-Behnken response surface methodology were as follows： soaking time of 23 min， stir-frying temperature of 160 ℃ ， and stir-frying time of 12 min， yielding a comprehensive score of 63.370 2. The GA-BP neural network optimization resulted in the following conditions： soaking time of 24 min， stir-frying temperature of 163 ℃， and stir-frying time of 12 min， with a comprehensive score of 65.163 8. The GA-BP neural network optimization outperformed the results obtained by Box-Behnken response surface methodology. CONCLUSIONS This study successfully optimized the salt-processing technology for A. asphodeloides. Specifically， the technology involves adding 15 mL of 0.1 g/mL saline solution to 50 g of the herbal slices， allowing them to moisten for 24 minutes， and then stir-frying at 163 ℃ for 12 minutes.
