Potential risks and countermeasures of autologous cell salvage
10.13303/j.cjbt.issn.1004-549x.2025.09.023
- VernacularTitle:自体血液回收潜在风险与应对措施
- Author:
Kang DU
1
;
Lei DU
1
;
Li ZHOU
1
Author Information
1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China
- Publication Type:Journal Article
- Keywords:
cell salvage;
red blood cell damage;
coagulation dysfunction;
immune modulation;
tumor cell clearance
- From:
Chinese Journal of Blood Transfusion
2025;38(9):1267-1271
- CountryChina
- Language:Chinese
-
Abstract:
Cell salvage (CS) is an important perioperative blood management technique that involves the real-time collection of shed blood from the surgical field, followed by washing and reinfusion into the patient. This approach effectively alleviates blood shortages and reduces the risks associated with allogeneic transfusion. With the widespread adoption of CS, its potential risks have drawn increasing attention. Mechanical shear stress during processing may impair the morphology and function of blood cells, while the centrifugation and washing steps can lead to substantial loss of coagulation components such as clotting factors and platelets. Additionally, transient leukocyte activation and suppression of immune cell function may contribute to perioperative immune dysregulation. Of particular concern is the limited capacity of current CS systems to eliminate pathogens and tumor cells, which may increase the risk of postoperative infection and tumor recurrence. Therefore, advancing CS technology by enhancing centrifugation performance, integrating efficient filtration systems to remove activated leukocytes, and enabling specific elimination of pathogens and malignant cells is essential for improving its safety profile. This review systematically summarizes the major challenges associated with clinical application of CS and aims to provide a reference for its standardized use, as well as a theoretical and practical foundation for future technological innovation and optimization.
