Research progress on polysaccharides in the cell wall of Mycobacterium tuberculosis
10.3969/j.issn.1006-2483.2025.05.030
- VernacularTitle:结核分枝杆菌细胞壁多糖研究进展
- Author:
Ming CAI
1
;
Jing ZHOU
2
;
Sijie YANG
1
;
Shidong ZHAO
1
;
Yan YIN
1
;
Fan CHEN
1
Author Information
1. Life Science School of Hubei University , Wuhan , Hubei 430062 , China
2. Clinical laboratory of Wuhan Pulmonary Hospita l, Wuhan 430030 , China
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
Cytoskeleton;
Polysaccharides;
Lipoarabinomannan
- From:
Journal of Public Health and Preventive Medicine
2025;36(5):134-139
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis, which is primarily transmitted through the respiratory tract, and remains one of the diseases with the highest mortality rate of single-pathogen infections globally. The cell wall polysaccharides of M. tuberculosis are critical for maintaining bacterial structure, mediating pathogenesis, and enabling immune evasion. Lipoarabinomannan (LAM), a key polysaccharide component, has revolutionized non-invasive diagnostic technologies as a TB biomarker, while polysaccharide-based vaccines have emerged as innovative strategies for TB prevention. This review systematically examines the composition, subcellular distribution, and functional roles of M. tuberculosis cell wall polysaccharides in bacterial metabolism, drug resistance, and immune regulation. A particular emphasis is placed on recent advancements in LAM-based diagnostics and vaccine development. Future studies should utilize advanced technologies to precisely characterize the structural features of TB polysaccharides and explore their biological functions, providing a foundation for targeted diagnostic and therapeutic innovations. This article aims to provide reference for advancing both basic research and clinical applications related to M. tuberculosis.
