Research Progress on Antitumor Mechanisms of EGCG
10.3971/j.issn.1000-8578.2025.25.0369
- VernacularTitle:EGCG抗肿瘤作用机制的研究进展
- Author:
Anke WU
1
;
Haiyang LI
2
;
Weiqi RONG
1
;
Ting XIAO
2
;
Jianxiong WU
1
Author Information
1. Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
2. State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
- Publication Type:REVIEWS
- Keywords:
Epigallocatechin gallate;
Antitumor;
Mechanism
- From:
Cancer Research on Prevention and Treatment
2025;52(9):776-780
- CountryChina
- Language:Chinese
-
Abstract:
Epigallocatechin gallate (EGCG), the most abundant catechin in green tea, possesses various biomedical activities and has garnered significant attention because of its notable anticancer properties. This article reviews the research progress on the antitumor mechanisms of EGCG, focusing on its roles in inducing tumor cell apoptosis; inhibiting tumor cell proliferation, angiogenesis, invasion and metastasis; modulating the tumor microenvironment; and influencing epigenetic modifications. Given its natural origin, safety, and low cost, EGCG could be a preferred option for the development of new cancer therapeutic drugs or enhancing the efficacy of combination therapies. This work aims to provide a theoretical foundation for further research and development of EGCG and scientific evidence for its application in cancer prevention and treatment.
