Expression Levels of α-SMA and Vimentin in Spindle Cells and Their Relationship with Prognosis of Patients with Myxofibrosarcoma
10.3971/j.issn.1000-8578.2025.25.0048
- VernacularTitle:α-SMA和梭形细胞Vimentin的表达及其与黏液纤维肉瘤患者预后的关系
- Author:
Guohui WU
1
;
Yan ZHANG
2
Author Information
1. Department of Pathology, The Fourth Medical Center, PLA General Hospital, Beijing 100048, China.
2. Shinshu University School of Medicine, Matsumoto 390-8621, Nagano Prefecture, Japan.
- Publication Type:CLINICALRESEARCH
- Keywords:
α-SMA;
Spindle cell Vimentin;
Myxofibrosarcoma
- From:
Cancer Research on Prevention and Treatment
2025;52(9):736-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression levels of a-smooth muscle actin (α-SMA) and Vimentin in spindle cells and their relationship with the prognosis of patients with myxofibrosarcoma (MFS). Methods The imaging, clinical, and pathological data of 61 patients with MFS were collected. All patients were confirmed by surgical and postoperative pathological examination. Immunohistochemical methods were used to determine the positive proportion of α-SMA and Vimentin. The correlation between the expression levels of α-SMA and Vimentin in spindle cells and prognosis was analyzed. Results The positive rates of α-SMA and Vimentin expression in MFS tissues were 68.85% and 60.66%, respectively. The expression of Vimentin was not significantly correlated with 3-year OS and DFS (P=0.351, P=0.284). The expression of α-SMA was significantly correlated with OS and DFS (P=0.030, P=0.017), and patients with high expression of α-SMA have shorter OS and DFS. Conclusion Determining α-SMA level can help evaluate the prognosis of patients with MFS and guide clinical treatment.
