Research progress of novel intraocular lens in the treatment of posterior cataract
10.3980/j.issn.1672-5123.2025.10.11
- VernacularTitle:新型人工晶状体在治疗后发性白内障中的研究进展
- Author:
Xinran ZHAI
1
;
Zhimin CHEN
1
;
Yanhui XU
1
;
Yue ZHANG
1
Author Information
1. Department of Ophthalmology Teaching and Research, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China; Hebei Eye Hospital;Hebei Provincial Key Laboratory of Ophthalmology;Hebei Provincial Clinical Research Center for Eye Diseases, Xingtai 054001, Hebei Province, China
- Publication Type:Journal Article
- Keywords:
posterior capsule opacification;
intraocular lens;
biomaterials;
surface modification
- From:
International Eye Science
2025;25(10):1611-1616
- CountryChina
- Language:Chinese
-
Abstract:
Posterior capsule opacification(PCO)is a common postoperative complication of cataract surgery, primarily caused by the proliferation and migration of residual lens epithelial cells(LECs). Although neodymium-doped yttrium aluminum garnet(Nd:YAG)laser posterior capsulotomy effectively treats PCO, it carries risks of complications such as cystoid macular edema(CME). Thus, preventing PCO formation is of critical clinical importance. Despite advancements in intraocular lens(IOL)materials and designs, achieving complete PCO eradication remains challenging. This review systematically examines recent advancements in surface-modified IOLs, including anti-biofouling IOL(reducing LECs adhesion), capsular adhesion-enhanced IOL(promoting capsular bag integration), micro-patterned IOL(physically inhibiting migration), photothermal/photodynamic IOL(inducing light-activated LECs apoptosis), and drug-eluting IOL(sustained drug release). These surface modification strategies demonstrate synergistic effects through complementary mechanisms(including physical barrier formation, chemical intervention, and bioactive regulation), effectively suppressing LECs proliferation while significantly reducing PCO incidence. Importantly, these approaches eliminate the risks associated with conventional Nd:YAG laser treatment, offering substantial advantages. By providing a comprehensive evaluation of these cutting-edge technologies, this review serves as a valuable reference for IOL design optimization. It represents a paradigm shift in cataract management strategies, transitioning from reactive therapeutic interventions to proactive preventive measures, and ultimately leads to improving long-term visual outcomes for patients.
