Research progress on relationship between endocrine disrupting chemicals from daily life and gestational diabetes mellitus
- VernacularTitle:日常生活来源的环境内分泌干扰物与妊娠期糖尿病关联的研究进展
- Author:
Le WANG
1
;
Beibei ZHU
1
;
Fangbiao TAO
1
Author Information
- Publication Type:Review
- Keywords: endocrine disrupting chemical; gestational diabetes mellitus; biological mechanism
- From: Journal of Environmental and Occupational Medicine 2025;42(8):987-993
- CountryChina
- Language:Chinese
- Abstract: The incidence of gestational diabetes mellitus (GDM) is gradually increasing and has become a significant public health issue. Endocrine disrupting chemicals (EDCs) are a ubiquitous class of exogenous chemical substances that can interfere with hormone synthesis, metabolism, and activity, and subsequently affect endocrine homeostasis. Humans are extensively and continuously exposed to various EDCs originating from food packaging, plastic products, textiles, electronic goods, as well as cleaning agents and cosmetics in daily life, leading to endocrine and metabolic disorders, such as obesity, insulin resistance, impaired glucose tolerance, and diabetes. Previous studies indicated a close association between EDCs exposure and the occurrence of GDM. This review summarized the correlation between daily life exposure to EDCs and GDM, along with their potential biological mechanisms, including bisphenols, phthalates, per- and polyfluoroalkyl substances, organophosphate esters, parabens, and triclosan, aiming to provide scientific evidence for supporting the effective implementation of public health intervention measures to alleviate and prevent GDM.
