Current Research on Modulation of NF-κB Signaling Network by Traditional Chinese Medicine to Intervene in Rheumatoid Arthritis
10.13422/j.cnki.syfjx.20251002
- VernacularTitle:中医药调控NF-κB信号网干预类风湿关节炎的研究现状
- Author:
Xuejuan LI
1
;
Ping YANG
1
;
Ting CHEN
2
;
Xixiang LI
1
Author Information
1. Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730050，China
2. Gansu University of Chinese Medicine，Lanzhou 730000，China
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
synovitis;
nuclear transcription factor-κB pathway;
signaling network;
inflammation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(18):286-294
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis （RA） is a chronic systemic autoimmune disease with complex pathogenesis， poor cure rate， long course of disease， and high disability rate， which seriously affects patients' quality of life. Western medicine treatment of RA mainly includes non-steroidal anti-inflammatory drugs， rheumatic drugs， glucocorticoids， biologics， and targeted small-molecule drugs， which have large side effects and many adverse reactions. Traditional Chinese medicine （TCM） has systematic， comprehensive， multi-target， and multi-mechanism advantages in the treatment of RA. Through the overall syndrome pattern identification， it is effective in relieving symptoms， delaying onset， and relieving pain in RA patients by dispelling wind and removing dampness， dissipating cold and dredging collaterals， clearing heat and removing toxin， resolving phlegm and removing blood stasis， and relaxing sinew and activating collaterals. In recent years， TCM has made remarkable progress in the intervention of RA by regulating the nuclear transcription factor-κB （NF-κB） signaling network. They include Toll-like receptor 4 （TLR4）， phosphoinositol 3 kinase （PI3K）/protein kinase B （Akt）， mitogen-activated protein kinase （MAPK）， Nod-like receptor protein 3 （NLRP3）， nuclear factor E2 associated factor 2 （Nrf2）， Janus kinase 2 （JAK2）/signaling and transcriptional activator 3 （STAT3）， and Toll-like receptor 2 （TLR2）. The regulatory mechanism of NF-κB signaling network is complex： TLR4 is the upstream receptor of NF-κB， PI3K/Akt and MAPK pathways can not only regulate the activity of NF-κB， but also serve as its downstream effect pathway， Nrf2 and NF-κB often have antagonistic effects in the regulation of inflammatory response. Therefore， the research progress of regulating NF-κB signaling network by traditional Chinese medicine in the intervention of RA was summarized to provide a reference for the treatment of RA disease and the development of new drugs.
