"Inflammation-cancer Transformation" Mechanism of Chronic Atrophic Gastritis and Intervention of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20251395
- VernacularTitle:慢性萎缩性胃炎“炎-癌”转化机制及中医药治疗研究进展
- Author:
Xinfang ZHANG
1
;
Wenzhao GUO
1
;
Chenyang YU
1
;
Guanhua LYU
2
Author Information
1. Graduate School，Liaoning University of Traditional Chinese Medicine（TCM），Shenyang 110847，China
2. The Second Affiliated Hospital of Liaoning University of TCM，Shenyang 110031，China
- Publication Type:Journal Article
- Keywords:
chronic atrophic gastritis;
inflammation-cancer transformation;
pathogenesis;
traditional Chinese medicine;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(17):295-304
- CountryChina
- Language:Chinese
-
Abstract:
“Inflammation-cancer” transformation of chronic atrophic gastritis （CAG） refers to the process in which the gastric mucosa， in the context of CAG， progresses through stages of precancerous lesions of gastric cancer （PLGC）， such as intestinal metaplasia and dysplasia， and eventually develops into gastric cancer （GC）. In China， the incidence and mortality rates of GC rank among the highest in the world， and the proportion of GC cases caused by gastric mucosal infection and inflammation has been increasing. Modern medical treatments for CAG and PLGC mainly rely on drug therapy， endoscopic resection， and regular surveillance. Although these disease management strategies are relatively mature， they present limitations in early lesion prevention and recurrence risk control. Therefore， it is imperative to identify therapeutic approaches for CAG and PLGC that offer preventive， reversible， and recurrence-reducing benefits. With advances in research on the mechanisms underlying inflammation-cancer transformation and the integration of traditional Chinese and Western medicine， the advantages of TCM in preventing and even reversing early-stage CAG and PLGC have gradually become apparent. This review explored the mechanisms of inflammation-cancer transformation in CAG from five aspects： inflammatory microenvironment， autophagy， glycolysis， bile acids， and ferroptosis. In conjunction with TCM theory and a deeper understanding of the distinct mechanisms involved in the inflammation-cancer transformation of CAG， this review further discussed the specific mechanisms through which TCM intervened in treating CAG and PLGC， with the aim of providing theoretical support and therapeutic insights for future clinical applications.
