Exploring Role of Energy Dyshomeostasis in Metabolic Dysfunction-associated Fatty Liver Disease Panvasculopathy from Theory of Liver Being Substantial Yin and Functional Yang
10.13422/j.cnki.syfjx.20251469
- VernacularTitle:基于“肝体阴用阳”探讨能量稳态失衡在代谢相关脂肪性肝病泛血管损伤中的作用
- Author:
Jing CUI
1
;
Qian XU
1
;
Wenting WANG
1
;
Mengmeng ZHU
1
;
Yanfei LIU
1
;
Yue LIU
1
Author Information
1. National Clinical Research Center for Chinese Medicine Cardiology，Xiyuan Hospital，China Academy of Chinese Medical Sciences，Beijing 100091，China
- Publication Type:Journal Article
- Keywords:
liver being substantial Yin and functional Yang;
metabolic dysfunction-associated fatty liver disease;
panvasculopathy;
energy metabolism;
imbalance of Yin and Yang;
atherosclerosis;
traditional Chinese medicine pathogenesis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(17):227-233
- CountryChina
- Language:Chinese
-
Abstract:
Liver being substantial Yin and functional Yang maintain normal function of Qi， blood and meridians. In clinical practice， it is often found that pan-vascular lesions with atherosclerosis as the predominant pathological change often co-occur with metabolic dysfunction-associated fatty liver disease（MAFLD）. MAFLD leads to increased risk and worse prognosis for many pan-vascular diseases， including cardiovascular disease. Dysregulation of energy homeostasis disrupts the hepatic homeostasis of body use， and representative drugs to improve metabolism， such as metformin， sodium-glucose co-transporter 2 inhibitors， and glucagon-like peptide-1 agonists， not only have a clear cardiovascular benefit， potential improvement of MAFLD has also been demonstrated. The liver stores blood and the heart pumps blood， and liver diseases affect the heart， that's why the unsmoothness of vessels appears. So the treatment should from the standpoint of liver， restoring liver function， soothing the liver and nourishing heart， activating blood and dredging meridian. It is of great significance to explore in depth the pathogenesis and treatment of pan-vascular lesions caused by MAFLD， and to restore the energy homeostasis by adjusting the balance of liver Yin and Yang.
