A case-control study on the association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus
10.12016/j.issn.2096-1456.202550185
- Author:
LIU Yuan
1
;
CHEN Yan
2
;
CONG Zhaoxia
1
;
LI Yiming
3
;
XUE Rui
3
;
ZHAO Jin
4
Author Information
1. Department of Endodontics, The First Affiliated Hospital, Xinjiang Medical University(The Affiliated Stomatological Hospital)
2. Department of Paediatric Dentistry-Preventive Dentistry, The First Affiliated Hospital, Xinjiang Medical University(The Affiliated Stomatological Hospital)
3. Department of Periodontal and Mucosal, the First Affiliated Hospital, Xinjiang Medical University (The Affiliated Stomatological Hospital)
4. Department of Endodontics, The First Affiliated Hospital, Xinjiang Medical University(The Affiliated Stomatological Hospital) 2Xinjiang Uygur Autonomous Region Institute of Stomatology.
- Publication Type:Journal Article
- Keywords:
oral lichen planus;
Hashimoto’s thyroiditis;
autoimmune diseases;
anti-thyroid antibodies;
thyroid peroxidase antibodies;
thyroglobulin antibodies;
antibody titers;
erosive lesions;
immune mechanisms
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(9):757-764
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to explore the association between oral lichen planus (OLP) and Hashimoto’s thyroiditis (HT) and its anti-thyroid antibodies to provide clinical evidence for thyroid disease screening in patients with OLP.
Methods:This study was approved by the institutional ethics committee. A total of 125 clinically and histopathologically confirmed patients with OLP were enrolled as the case group, and they were matched with 125 non-OLP controls based on sex and age. Demographic data (gender, age, lesion type, and disease duration) were collected from both groups. Serum levels of thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb) were measured to analyze their associations with sex, age, lesion type, and disease duration in patients with OLP.
Result:The prevalence of HT in patients with OLP was 31.20%, significantly higher than that in the control group (9.60%) (χ2=18.504, P<0.001). The prevalence of HT in female patients with OLP (39.13%) was significantly higher than that in male patients (9.09%)（χ2=10.93，P<0.001）. The positivity rate of thyroid peroxidase antibodies (TPOAb) in patients with OLP (17.6%) was significantly higher than in the control group (4.0%) (χ2=10.989, P<0.001). The TPOAb positivity rate was significantly higher in female patients (22.83%) than in male patients (3.03%) (χ2=5.210, P=0.014). There was no statistically significant difference in the positivity rate of TgAb between patients with OLP (7.2%) and the control group (3.2%) (P>0.05). Patients with erosive lesions had a significantly higher TPOAb positivity rate (25.0%, 17/68) compared to those with non-erosive lesions (8.77%, 5/57), and the difference was statistically significant (χ2=4.831, P=0.028). Logistic regression analysis revealed that female patients with OLP had an 8.935-fold higher risk of being TPOAb positive compared to males (OR=8.935, 95%CI: 1.134-70.388, P=0.038). Patients with erosive OLP lesions had a 3.199-fold higher risk of TPOAb positivity compared to those with non-erosive lesions (OR=3.199, 95%CI: 1.064-9.618, P=0.038).
Conclusion:The prevalence of HT is higher in patients with OLP, with higher positivity rates of anti-thyroid antibodies observed in female patients and those with erosive OLP lesions. This suggests that thyroid disease screening should be incorporated into the clinical management of patients with OLP, especially for women and patients who present with erosive lesions.
- Full text:202509051130505088口腔扁平苔藓与桥本甲状腺炎及其抗甲状腺抗体关联性的病例对照研究.pdf
