Characteristics of smooth pursuit eye movement and optokinetic nystagmus on videonystagmography in patients with multiple system atrophy， cerebellar type
10.19845/j.cnki.zfysjjbzz.2025.0140
- VernacularTitle:多系统萎缩C型患者平稳跟踪和视动性眼震试验的视频眼震电图特点
- Author:
Fang CHEN
1
;
Chunqiu FAN
1
Author Information
1. 首都医科大学宣武医院神经内科，北京 100053
- Publication Type:Journal Article
- Keywords:
Multiple system atrophy， cerebellar type;
Smooth pursuit;
Optokinetic nystagmus;
Early diagnosis
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(8):736-740
- CountryChina
- Language:Chamorro
-
Abstract:
Objective To investigate the characteristics of smooth pursuit eye movement and optokinetic nystagmus on videonystagmography in patients with multiple system atrophy， cerebellar type （MSA-C）， and to provide electrophysiological information for the early diagnosis of MSA-C.Methods A total of 30 patients with MSA-C who were diagnosed and treated in Department of Neurology， Xuanwu Hospital， Capital Medical University， from May 2022 to December 2023 were enrolled as subjects （MSA-C group）， and 30 healthy individuals were enrolled as control group. The parameters of smooth pursuit eye movement and optokinetic nystagmus were analyzed for the 30 patients with MSA-C. The parameters of smooth pursuit eye movement included waveform， velocity-dependent gain， left-right gain balance， and comparison of waveform abnormality rates versus gain abnormality rates， and the parameters of optokinetic nystagmus included direction， slow phase velocity （SPV） symmetry， and mean gains across different velocities； a comparative analysis was performed for the proportion of patients with optokinetic nystagmus gain abnormalities and those with smooth pursuit gain abnormalities.Results Compared with the control group， the MSA-C group had a significantly higher proportion of patients with abnormal waveforms in smooth pursuit test （90.0% vs 13.3%） and significantly lower mean smooth pursuit gains of 20°/s and 40°/s， and such different became more significant with the increase in velocity. There was no significant difference in mean smooth pursuit gain between the MSA-C patients with different velocities， and among the MSA-C patients， the patients with waveform abnormalities accounted for a significantly higher proportion than those with gain abnormalities （90.0% vs 16.7%）. The patients with MSA-C had normal direction and bilateral SPV symmetry for optokinetic nystagmus， and the MSA-C group had significantly lower mean gains across different velocities than the control group. Among the MSA-C patients， the patients with a reduction in optokinetic nystagmus gain accounted for a significantly higher proportion than those with a reduction in smooth pursuit gain.Conclusion Compared with the control group， the patients with MSA-C had a reduction in smooth pursuit gain， which became more significant with the increase in velocity. In patients with MSA-C， abnormal smooth pursuit waveforms were more sensitive than gain reduction and may serve as an electrophysiological indicator for the early diagnosis of MSA-C. Compared with the control group， the patients with MSA-C had a reduction in optokinetic nystagmus gain， which was more sensitive than smooth pursuit gain reduction. In conclusion， waveform abnormalities in smooth pursuit test and the reduction in optokinetic nystagmus gain are important electrophysiological indicators for the early diagnosis of MSA-C.
- Full text:2025090414053356227多系统萎缩C型患者平稳跟踪和视动性眼震试验的视频眼震电图特点.pdf
