The role of neuroimmune interactions in the pathogenesis and chronicity of migraine
10.19845/j.cnki.zfysjjbzz.2025.0115
- VernacularTitle:神经免疫在偏头痛发生与慢性化过程中的作用
- Author:
Peng YU
1
;
Ming DONG
2
Author Information
1. 吉林大学第二医院眼科中心眼底病科，吉林 长春 130041
2. 吉林大学第一医院神经内科和神经科学中心，吉林 长春 130021
- Publication Type:Journal Article
- Keywords:
Migraine;
Pathogenesis;
Neuroimmune interactions
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(7):605-609
- CountryChina
- Language:Chinese
-
Abstract:
Migraine is a debilitating neurological disorder commonly observed in clinical practice，and its pathogenesis is closely associated with abnormal activation and sensitization of the trigeminovascular system.Recent studies have shown that neuroimmune interactions play a pivotal role in the pathophysiological process of migraine.This article systematically reviews the multidimensional clinical evidence for the link between immune system dysregulation and the development of migraine， covering the aspects of genetic susceptibility， inflammatory factors in peripheral circulation，and neuroimaging features of the central nervous system. Furthermore， this article discusses the latest research advances based on rodent animal models， which reveals the dynamic recruitment of diverse immunocompetent cells，including innate immune cells， adaptive immune cells， and neuroglial cells， across the hierarchical structures of the trigeminovascular pathway. These immune effector cells bidirectionally modulate neuronal excitability through the complex network of pro-inflammatory and anti-inflammatory mediators， thereby participating in the formation of peripheral and central sensitization. This article especially focuses on the potential application value of these fundamental research findings in clinical translation.
- Full text:2025081113541365419神经免疫在偏头痛发生与慢性化过程中的作用.pdf
