Current research status of ferroptosis in Parkinson disease：A visual analysis based on CiteSpace
10.19845/j.cnki.zfysjjbzz.2025.0086
- VernacularTitle:基于CiteSpace对帕金森病铁死亡研究现状的可视化分析
- Author:
Sujun GUO
1
;
Bo ZHOU
2
;
Li MA
2
Author Information
1. 宁夏医科大学，宁夏 银川 750004
2. 宁夏医科大学，宁夏 银川 750004;宁夏少数民族医药现代化重点实验室，宁夏 银川 750001
- Publication Type:Journal Article
- Keywords:
Ferroptosis;
Parkinson disease;
CiteSpace;
Visual analysis
- MeSH:
Parkinson Disease
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(5):459-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the current research status of ferroptosis in Parkinson disease in recent years. Methods CiteSpace was used to perform bibliometric and visual analyses of the articles on the mechanism of action of ferroptosis in Parkinson disease and related prevention and treatment measures in CNKI and Web of Science （WoS）. Results A total of 92 articles from CNKI and 273 articles from WoS were included in this study. There was a tendency of increase in the number of articles published in China and globally. In CNKI， the keywords of ferroptosis， Parkinson's disease， oxidative stress， and traditional Chinese medicine were cited for many times， while in WoS， activation， cell death， alpha-synuclein， and Parkinson disease were cited for many times. There were 7 clusters of keywords in CNKI and 12 clusters in WoS. The top 5 authors （teams） in terms of the number of publications in CNKI were Yang Xinling； Zhang Lijie； Li Shaodan； Hao Mengdie； and Lu Ranran， while the top 5 authors （teams） in WoS were Ayton， Scott； Zhu， Meiling； Qu， Le； Devos， David； and Xie， Junxia. The number of team members in China was lower than that in foreign countries， mainly small team cooperation. As for the number of articles published by institutional cooperation， Qingdao University published the highest number of articles in CNKI， while the University of Melbourne published the highest number of articles in WoS. Biochemistry was the subject with the highest frequency， and there were intersections between disciplines. China was the core representative of state cooperation with the highest frequency. Conclusion The research on the association between Parkinson disease and ferroptosis mainly focuses on oxidative stress， neuroprotection， traditional Chinese medicine， and neuroinflammation， among which neuroprotection and neuroinflammation are the latest trends for development. Therefore， there may be more targeted therapies for neuroinflammation and therapies that stimulate neuroprotection in the future to alleviate pain and improve the quality of life of patients.
