Sensorimotor， associative and limbic loops in patients with an initial diagnosis of Parkinson disease： A functional magnetic resonance imaging study
10.19845/j.cnki.zfysjjbzz.2025.0084
- VernacularTitle:初诊帕金森病感觉运动、联想和边缘环路的功能核磁研究
- Author:
Hui ZHAO
1
;
Jie ZU
1
Author Information
1. 徐州医科大学附属医院神经内科，江苏 徐州 221006;徐州医科大学第一临床医学院，江苏 徐州 221001
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Functional magnetic resonance imaging;
Cortical-striatal loop;
Habitual control;
Goal-directed behavior
- MeSH:
Parkinson Disease
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(5):447-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in functional connectivity （FC） of cortical-striatal sensorimotor loop （mediating habit control）， associative loop （regulating goal-directed behavior）， and limbic loop in patients with an initial diagnosis of Parkinson disease （PD）. Methods Resting-state functional magnetic resonance imaging data were collected from 41 PD patients and 31 healthy controls. The cortical and basal ganglia regions associated with the sensorimotor， associative， and limbic loops were selected as regions of interest （ROIs）， and FC between each region of interest was calculated. The magnetic resonance images of the more affected hemisphere were aligned to exclude severe lateralization of symptoms. The correlation analysis was conducted to investigate the correlation between FC and disease severity. Results The patients with PD showed a reduction in FC within the sensorimotor loop， specifically between the left dorsolateral striatum and the left sensorimotor cortex （P<0.001）， between the right dorsolateral striatum and the left sensorimotor cortex （P=0.004）， and between the right dorsolateral striatum and the right sensorimotor cortex （P=0.004）， and there was no significant change in FC within the associative loop. The patients with PD showed a reduction in FC within the limbic loop between the bilateral ventral striata （P<0.001）. In the PD group， FC between the left dorsolateral striatum and the left sensorimotor cortex was negatively correlated with MDS-UPDRS Ⅲ score （r=-0.496， P=0.001）， with consistent results after alignment of the side with more severe symptoms. Conclusion There is a pathological reduction in FC within the sensorimotor loop that is involved in habitual control in the early stage of PD， while the associative loop for regulating goal-directed behavior remains unaffected or may be involved in early compensatory processes.
- Full text:2025071708481853499初诊帕金森病感觉运动、联想和边缘环路的功能核磁研究.pdf
