Stiff-person syndrome with positive anti-amphiphysin antibodies： A case report and literature review
10.19845/j.cnki.zfysjjbzz.2025.0063
- VernacularTitle:抗Amphiphysin抗体阳性的僵人综合征1例报告并文献复习
- Author:
Chengxia LI
1
;
Kaiming LIU
2
;
Laixi LI
1
Author Information
1. 广德市人民医院神经内科，安徽 广德 242200
2. 浙江大学医学院附属第二医院神经内科，浙江 杭州 310002
- Publication Type:Journal Article
- Keywords:
Stiff-person syndrome;
Anti-amphiphysin antibodies;
Neuroimmunology
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(4):316-320
- CountryChina
- Language:Chinese
-
Abstract:
Stiff-person syndrome （SPS） is a rare autoimmune neurological disorder with atypical symptoms and signs，which often leads to missed diagnosis or misdiagnosis，resulting in delayed treatment. This article reports a female patient，aged 72 years，who was diagnosed with SPS，and her symptoms were improved after symptomatic treatment including intravenous injection of human immunoglobulin，corticosteroids，clonazepam，and baclofen. It is suggested that early diagnosis and timely treatment can improve the quality of life and prognosis of SPS patients with positive anti-amphiphysin antibodies.
- Full text:2025071613542680825抗Amphiphysin抗体阳性的僵人综合征1例报告并文献复习.pdf
