Effect of cerebral white matter lesion on the symptoms of Parkinson disease
10.19845/j.cnki.zfysjjbzz.2025.0027
- VernacularTitle:脑白质病变对帕金森病相关症状的影响
- Author:
Ai ZHAO
1
;
Jing BAI
1
Author Information
1. Department of Neurology， The First Hospital of Jilin University，Changchun 130021， China
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
White matter lesion;
Motor symptoms;
Non-motor symptoms
- MeSH:
Parkinson Disease
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(2):137-142
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson’s disease （PD） is a common neurodegenerative disease with a high incidence rate in the elderly population， and its complex pathogenesis involves α-synuclein misfolding and aggregation， mitochondrial dysfunction， neuroinflammation， and oxidative stress， resulting in different impairments of motor and non-motor symptoms and a bad influence on the quality of life of patients. White matter lesion （WML） is a neurodegenerative disease caused by damage to myelin sheath tissue in the central nervous system of the brain， with the pathogenesis of endothelial damage， hypoperfusion of brain white matter， and impairment of blood-brain barrier. WML causes varying degrees of impairment in postural instability， gait disturbance， and motor retardation in PD patients and exerts a certain degree of negative effects on cognitive function and sleep， anxiety， depression， and autonomic nervous function in PD patients. This article reviews the pathogenesis of PD and WML and the damage or influence of WML on the motor and non-motor symptoms of PD， in order to elaborate on the association between WML and PD.
- Full text:2025071514340681278脑白质病变对帕金森病相关症状的影响.pdf
