Retrospective analysis of clinical efficacy of Nuangong Waifu formula in preventing intrauterine re-adhesion
10.12206/j.issn.2097-2024.202411013
- VernacularTitle:暖宫外敷方预防宫腔再粘连临床疗效回顾性分析
- Author:
Xuemei DI
1
;
Wen SHUAI
1
;
Qiqiang ZHANG
1
;
Meixiang YU
1
;
Hai ZHANG
1
;
Yonghong NIE
1
Author Information
1. Department of Pharmacy, b. Hysteroscopy Center, c. Department of Traditional Chinese Medicine, Obstetrics and Gynecology Hospital of Tongji University, Shanghai 201204 , China.
- Publication Type:Medicine&Clinical
- Keywords:
uterine adhesions;
Nuangong Waifu formula;
clinical efficacy;
retrospective analysis
- From:
Journal of Pharmaceutical Practice and Service
2025;43(7):353-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective The Nuangong Waifu formula （NGWFF） is a traditional Chinese medicine prescription that has been used in gynecology of traditional Chinese medicine in our hospital for many years. It has a certain effect on preventing postoperative intrauterine re-adhesion. To further retrospectively analyze the clinical efficacy of NGWFF. Methods A total of 200 patients who were diagnosed with intrauterine adhesions and underwent intrauterine adhesion separation from January 2018 to December 2020 were retrospectively included. They were divided into control group and observation group according to different drug use for postoperative prevention of re-adhesion, with 100 cases in each group. All patients were given oral estrogen and progesterone （ethinyl estradiol tablets 0.037 5 mg, q12 h, or estradiol valerate tablets 3 mg, q12 h, a total of 21 days, 7 days after estrogen therapy plus dydrogesterone 20 mg, qd or progesterone capsules 200 mg, qd） to promote endometrial growth. In the control group, 100 patients only used estrogen and progesterone after operation. In the observation group, 100 patients were treated with NGWFF at Guanyuan acupoint （four fingers under the navel）, once a day. Both groups were evaluated for the degree of intrauterine adhesions under hysteroscopy and the effective rate after 3-5 menstrual cycles of drug treatment. Results Compared with using estrogen and progesterone alone, combination use of NGWFF significantly decreased in the scores of intrauterine adhesions under hysteroscopy （2.41±1.19 vs 3.31±1.18, P=0.00）, and the effective rate was also significantly higher than that in the control group （ 86 % vs 47 %, P<0.000）. Conclusion The combination use of NGWFF was more effective than using estrogen and progesterone alone in preventing re-adhesion after intrauterine adhesions， which provided a scientific basis for the clinical application of NGWFF.
