A case report of Whipple’s disease presenting as mediastinal abscess
10.12025/j.issn.1008-6358.2025.20250404
- VernacularTitle:以纵隔脓肿为主要表现的惠普尔病1例报告
- Author:
Zhengyi HUANG
1
;
Taoran BI
2
;
Bingbing LU
2
;
Zhancheng GAO
2
Author Information
1. Department of Geriatrics, Peking University People’s Hospital, Beijing 100044, China.
2. Department of Pulmonary and Critical Care Medicine, Peking University People’s Hospital, Beijing 100044, China.
- Publication Type:Clinicalcaseanalysis
- Keywords:
Whipple’s disease;
Tropheryma whipplei;
meta-genomics next generation sequencing;
mediastinal abscess
- From:
Chinese Journal of Clinical Medicine
2025;32(3):519-523
- CountryChina
- Language:Chinese
-
Abstract:
In February 2023, a 48-year-old male with cough and expectoration was admitted to the Department of Pulmonary and Critical Care Medicine of Peking University People’s Hospital. CT indicated mediastinal soft-tissue mass under the tracheal carina. Meta-genomics next generation sequencing of mediastinal abscess suggested infection with Tropheryma whipplei, which was positive for periodic acid-Schiff staining. The patient had no history of diarrhea, weight loss, or joint pain. The patient was diagnosed with Whipple’s disease and treated with ceftriaxone followed by trimethoprim-sulfamethoxazole therapy. After 1-year post-discharge therapy, the patieny’s symptoms and general condition improved significantly, and remained to follow.
