Clinical characteristics of Kennedy's disease： a report of three cases and literature review
10.19845/j.cnki.zfysjjbzz.2024.0071
- VernacularTitle:肯尼迪病3例临床特征分析并文献复习
- Author:
Yazhen BAI
1
;
Qizhi FU
2
Author Information
1. 河南科技大学临床医学院，河南科技大学第一附属医院，河南 洛阳 471003
2. 河南科技大学第一附属医院神经内科，河南 洛阳 471003
- Publication Type:Journal Article
- Keywords:
Kennedy's disease;
Spinal and bulbar muscular atrophy;
Clinical characteristics
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(4):365-368
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of Kennedy's disease （KD）. Methods We reported three cases of KD confirmed by genetic testing admitted to the Department of Neurology of The First Affiliated Hospital of Henan University of Science and Technology. Based on their clinical manifestations， physical examination results， and auxiliary examination data as well as previous literature， we analyzed and summarized the clinical features of KD. Results The three male KD patients were aged 43-46 years. They mainly manifested with progressive slurred speech， limb weakness， tongue muscle atrophy with tremor， and breast development. Creatine kinase levels were increased and sex hormone levels were abnormal in all the patients. Electromyography showed extensive neurogenic damage with involvement of both motor and sensory nerves. Genetic testing detected over 40 CAG repeats in the androgen receptor gene in all the cases. Conclusion KD is a late-onset inherited motor neuron disease， which can involve multiple systems to cause various clinical manifestations. Genetic testing is needed for a definite diagnosis.
- Full text:2025071009040581526肯尼迪病3例临床特征分析并文献复习.pdf
