Research advances in cerebral small vessel disease and cognitive impairment
10.19845/j.cnki.zfysjjbzz.2024.0059
- VernacularTitle:脑小血管病与认知障碍的研究进展
- Author:
Heng ZHANG
1
;
Yifeng DU
1
Author Information
1. Department of Neurology， Shandong Provincial Hospital Affiliated to Shandong First Medical University， Jinan 250021， China
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel disease;
Cognitive impairment;
Pathological mechanisms;
Prevention and treatment
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(4):298-304
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral small vessel disease （CSVD） is a series of clinical， imaging， and pathological syndromes mainly caused by small vessel lesions， and it often has an insidious onset， diverse manifestations， and a low rate of early identification， which are the common reasons for gradual progression to cognitive impairment. It is worth noting that CSVD-related cognitive impairment is not limited to vascular cognitive impairment， and it can also involve other neurodegenerative diseases such as Alzheimer disease and Parkinson disease dementia. Therefore， precise identification， early diagnosis， and intervention are of great importance in controlling the development and damage of CSVD-related cognitive impairment. Given the complex pathological mechanisms and classifications of CSVD and the fact that the association between CSVD and the progression of cognitive impairment cannot be neglected， this article provides a comprehensive understanding of the etiology， pathogenesis， pathology， and imaging subtypes of CSVD and reviews the association between CSVD and various cognitive impairment diseases， so as to provide a reference for the clinical multimodal evaluation， prevention， and treatment of CSVD-related cognitive impairment.
- Full text:202507091627510396脑小血管病与认知障碍的研究进展.pdf
