The role of Nrf2 in hematoma clearance and neuroprotection after intracerebral hemorrhage and the underlying mechanism
10.19845/j.cnki.zfysjjbzz.2024.0034
- VernacularTitle:Nrf2在脑出血后血肿清除及脑保护中的作用及机制
- Author:
Bude LI
1
;
Gaiqing WANG
2
Author Information
1. 海南医学院第一临床学院，海南 海口 570100;三亚中心医院（海南省第三人民医院），海南医学院，海南 三亚 572000
2. 三亚中心医院（海南省第三人民医院），海南医学院，海南 三亚 572000
- Publication Type:Journal Article
- Keywords:
Intracerebral hemorrhage;
Nuclear factor erythroid 2-related factor 2;
Nuclear factor erythroid 2-related factor 2 agonist;
Xuezhikang;
Hematoma clearance
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(2):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Intracerebral hemorrhage（ICH）is a cerebrovascular disease with high morbidity，mortality，and disability. As hematoma is the key driver of brain injury after ICH，early removal of hematoma components is crucial for preventing and reducing early brain damage following ICH. Existing treatments for ICH are limited in effectiveness，and recent preclinical trials have revealed some exciting findings，including an interesting new target—nuclear factor erythroid 2-related factor 2（Nrf2）. Nrf2 is a transcription factor that may play a neuroprotective role by activating cellular repair mechanisms through different pathways，and its therapeutic potential has attracted great interest in research. This article summarizes the role of Nrf2 and its agonists in post-ICH hematoma clearance and neuroprotection and the underlying mechanism.
- Full text:2025070909411276032Nrf2在脑出血后血肿清除及脑保护中的作用及机制.pdf
