Traditional Chinese Medicine Regulates SIRT Protease Family to Treat Renal Fibrosis： A Review
10.13422/j.cnki.syfjx.20250807
- VernacularTitle:中医药调控SIRT蛋白酶家族防治肾纤维化研究进展
- Author:
Jinglu ZHANG
1
;
Lixia JIN
2
;
Xiaodong ZHANG
2
;
Runshneg LIU
1
;
Zhe JIANG
1
Author Information
1. Heilongjiang University of Chinese Medicine，Harbin 150006，China
2. The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150070，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
renal fibrosis;
sirtuin family;
oxidative stress;
fatty acid oxidation;
mitochondrial function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(15):306-314
- CountryChina
- Language:Chinese
-
Abstract:
Renal fibrosis （RF） is the primary pathological feature of chronic kidney disease （CKD） progression to end-stage renal disease （ESRD）， with glomerulosclerosis and tubulointerstitial fibrosis as core pathological manifestations. It involves abnormal accumulation of extracellular matrix （ECM） components such as collagen and fibronectin， ultimately leading to structural destruction and functional losses of the kidneys. Sirtuins （SIRTs）， a class of nicotinamide adenine dinucleotide （NAD+）-dependent deacetylases， play crucial roles in cellular metabolism， oxidative stress responses， inflammation regulation， and cell survival. In mammals， there are seven distinct SIRT members （SIRT1 to SIRT7）， which collectively ameliorate RF progression through multiple pathways. These include regulating the transforming growth factor （TGF）-β/Smad signaling pathway， suppressing inflammatory responses， reducing oxidative stress， modulating mitochondrial and autophagy functions， and promoting fatty acid oxidation. In recent years， traditional Chinese medicine （TCM） and its active components have demonstrated significant potential in activating or modulating the SIRT protease family and its regulatory networks to ameliorate RF in a multi-target and holistic manner. However， systematic reviews in this area remain lacking. This article elucidates the mechanisms by which the SIRT protease family regulates RF and reviews the latest research advances in TCM modulation of SIRTs for the prevention and treatment of RF， aiming to provide new insights and approaches for the TCM treatment of RF.
