Cross-Sectional Observation of the Factors for Long-Term Maintenance of Long-Acting Injectable Antipsychotics in Schizophrenia
- Author:
Hyuk GWON
1
;
Bo-Hyun YOON
;
Kyungmin KIM
;
Hangoeunbi KANG
;
Hyunju YUN
;
Yuran JEONG
;
Ha-Ran JUNG
;
Jye-Heon SONG
;
Suhee PARK
;
Young-Hwa SEA
;
Jaegil JO
Author Information
- Publication Type:Original Article
- From: Mood and Emotion 2024;22(3):69-77
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:This study aimed to identify factors that influence the maintenance of long-acting injectable antipsychotics (LAI) for over a year in patients with schizophrenia.
Methods:Seventy patients from Naju National Hospital were divided into two groups: those who maintained LAI for over a year (maintaining group, n=39) and those who discontinued (dropout group, n=31). Sociodemographic and clinical factors were compared using medical records and assessments, including the Birchwood Insight Scale (BIS), Drug Attitude Inventory-10 (DAI-10), and World Health Organization Quality of Life assessment instrument.
Results:The number of rehospitalizations was significantly lower in the maintaining group (p=0.030). The highest previous Global Assessment of Functioning Scale score within a year of starting LAI was significantly higher in the maintaining group (p=0.002), with a higher number of individuals being employed in this group (p=0.029). The mean BIS (p=0.010) and DAI-10 (p=0.003) scores were higher in the maintaining group. Logistic regression analysis revealed that the DAI-10 (B=0.148, p=0.014) had a significant impact on maintaining LAI.
Conclusion:Our study suggests that a positive drug attitude is one of the key factors in maintaining LAI treatment, preventing relapses and supporting long-term stabilization in schizophrenia.
