A Literature Review and Preliminary Study on Proteomic Research Associated With the Therapeutic Mechanism and Efficacy of Electroconvulsive Therapy in Schizophrenia Patients
10.16946/kjsr.2025.28.1.19
- Author:
Jiseon JANG
1
;
Minah KIM
;
Dohyun HAN
;
Woncheol KIM
;
Junsoo KWON
Author Information
1. Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea
- Publication Type:Review
- From:Korean Journal of Schizophrenia Research
2025;28(1):19-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The mechanism of electroconvulsive therapy (ECT) in schizophrenia remains unclear, with limited research available. Previous studies have reported ECT-induced changes in protein markers, including neurotrophic factors, inflammatory markers, and signaling proteins, but findings have been inconsistent. This study reviews existing literature on protein changes associated with ECT and explores potential molecular mechanisms underlying its effects. Additionally, we present pilot findings from 34 patients with schizophrenia or schizoaffective disorder who underwent ECT at Seoul National University Hospital. Blood samples collected before and after ECT were analyzed via liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify differentially expressed proteins (DEPs), with Pearson’s correlation analysis examining their association with symptom changes. Talin 2 emerged as a potential biomarker linked to clinical improvement. However, given the small sample size, these findings require cautious interpretation. Further research is needed to clarify the molecular mechanisms underlying ECT’s therapeutic effects in schizophrenia.
