Radiological and Pathological Challenges in Diagnosing Pleomorphic Lobular Carcinoma In Situ With Focal Invasion: A Case Report

Author: Hyo-jae LEE ¹ ; Chan PARK ; Won Gi JEONG ; Ji Shin LEE ; Min Ho PARK ; Hyo Soon LIM
Author Information

1. Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea
Publication Type:3
From: Journal of Breast Disease 2024;12(2):33-36
CountryRepublic of Korea
Language:English
Abstract: Pleomorphic lobular carcinoma in situ (PLCIS) is a relatively uncommon subtype of lobular neoplasia, characterized by large pleomorphic discohesive cells exhibiting marked nuclear atypia, frequent central comedo-necrosis, and microcalcifications. Owing to these features, PLCIS is difficult to distinguish using radiological and histological analyses with high-grade ductal carcinoma in situ. This report presents a case in which breast PLCIS was initially misdiagnosed as invasive ductal carcinoma based on core-needle biopsy and radiological findings. However, further investigation confirmed the diagnosis of PLCIS with invasive lobular carcinoma, measuring only 1.04 mm. This case illustrates the diagnostic challenges of PLCIS, which mimics invasive ductal carcinoma, causing unnecessarily aggressive treatment. Notably, this warrants careful pathological and radiological evaluations for accurate diagnosis and guides appropriate management.