Evolving Therapeutic Strategies in Esophageal Squamous Cell Carcinoma: Advances and Perspectives
- Author:
Zhibin LIU
1
;
Myoung Ok KIM
Author Information
- Publication Type:Review
- From:Journal of Cancer Prevention 2024;29(4):99-104
- CountryRepublic of Korea
- Language:English
- Abstract: Esophageal squamous cell carcinoma (ESCC) is among the most prevalent forms of esophageal cancer globally, with a particularly high incidence in developing countries. Notably, Asia accounts for approximately 80% of global esophageal cancer cases, with China alone contributing to 54% of this burden. The primary treatment modality for ESCC remains esophagectomy, primarily employed for locally advanced disease, often in combination with chemotherapy and radiotherapy for advanced-stage cases. Despite significant advancements in surgical techniques and the advent of precision medicine, which has facilitated the development of targeted and immune-based therapies, critical challenges persist, including suboptimal therapeutic efficacy and the emergence of drug resistance. A comprehensive understanding of the current treatment landscape for ESCC is essential to overcoming these barriers and improving patient outcomes.
