Complement C5a Receptor Signalingin Macrophages Enhances Trained Immunity Through mTOR Pathway Activation
- Author:
Eun-Hyeon SHIM
1
;
Sae-Hae KIM
;
Doo-Jin KIM
;
Yong-Suk JANG
Author Information
- Publication Type:Brief Communication
- From:Immune Network 2024;24(4):e24-
- CountryRepublic of Korea
- Language:English
- Abstract: Complement C5a receptor (C5aR) signaling in immune cells has various functions, inducing inflammatory or anti-inflammatory responses based on the type of ligand present. The Co1 peptide (SFHQLPARSRPLP) has been reported to activate C5aR signaling in dendritic cells. We investigated the effect of C5aR signaling via the Co1 peptide on macrophages. In peritoneal macrophages, the interaction between C5aR and the Co1 peptide activated the mTOR pathway, resulting in the production of pro-inflammatory cytokines. Considering the close associations of mTOR signaling with IL-6 and TNF-α in macrophage training, our findings indicate that the Co1 peptide amplifies β-glucan-induced trained immunity. Overall, this research highlights a previously underappreciated aspect of C5aR signaling in trained immunity, and posits that the Co1 peptide is a potentially effective immunomodulator for enhancing trained immunity.
