Nutritional Status in Adults with Predialysis Chronic Kidney Disease: KNOW-CKD Study.
10.3346/jkms.2017.32.2.257
- Author:
Young Youl HYUN
1
;
Kyu Beck LEE
;
Seung Hyeok HAN
;
Yeong Hoon KIM
;
Yong Soo KIM
;
Sung Woo LEE
;
Yun Kyu OH
;
Dong Wan CHAE
;
Curie AHN
Author Information
1. Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. kyubeck.lee@samsung.com
- Publication Type:Original Article
- Keywords:
Nutrition;
Protein-Energy Wasting;
Inflammation;
Chronic Kidney Disease
- MeSH:
Adult*;
C-Reactive Protein;
Cohort Studies;
Glomerular Filtration Rate;
Humans;
Inflammation;
Logistic Models;
Metabolism;
Motor Activity;
Nutritional Status*;
Prevalence;
Renal Insufficiency, Chronic*
- From:Journal of Korean Medical Science
2017;32(2):257-263
- CountryRepublic of Korea
- Language:English
-
Abstract:
Adverse changes in nutrition are prevalent and are strong indicators of adverse outcomes in patients with chronic kidney disease (CKD). The International Society of Renal Nutrition and Metabolism (ISRNM) proposed a common nomenclature and diagnostic criteria to identify protein-energy wasting (PEW) in CKD patients. We examined the nutritional status in 1,834 adults with predialysis CKD enrolled in the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD) study. As there was a need for further understanding of nutritional status and associated factors in CKD, we evaluated the prevalence and associated factors of PEW in adults with predialysis CKD. The prevalence of PEW was about 9.0% according to ISRNM criteria and tended to increase with advanced stage in predialysis CKD. Those who concurrently had PEW, inflammation, and CVD were a small proportion (0.4%). In multivariate logistic regression model, PEW was independently associated with estimated glomerular filtration rate (eGFR) (odds ratio [OR], 0.98; 95% confidence interval [CI], 0.96–0.99), total CO2 (OR, 0.93; 95% CI, 0.87–0.99), physical activity (OR, 0.43; 95% CI, 0.26–0.69), comorbid diabetes (OR, 1.68; 95% CI, 1.09–2.59), and high sensitivity C-reactive protein (hs-CRP) (OR, 1.03; 95% CI, 1.01–1.06). Our study suggests that PEW increases with advanced CKD stage. PEW is independently associated with renal function, low total CO2, low physical activity, comorbid diabetes, and increased hs-CRP in adults with predialysis CKD.
