Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis.
- Author:
Tae Young HAN
1
;
Tae Seok KONG
;
Min Ho KIM
;
Jeong Don CHAE
;
June Hyun Kyung LEE
;
Sook Ja SON
Author Information
- Publication Type:Original Article
- Keywords: 25-Hydroxyvitamin D; Atopic dermatitis; LL-37; SCORAD
- MeSH: Adult*; Body Mass Index; Child*; Dermatitis, Atopic*; Humans; Prevalence; Vitamin D*
- From:Annals of Dermatology 2015;27(1):10-14
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Vitamin D insufficiency could be associated with the prevalence of atopic dermatitis (AD). OBJECTIVE: To examine vitamin D status and the relations between serum 25-hydroxyvitamin D levels, SCORAD score, serum LL-37 level, and body mass index (BMI) in Korean AD patients, and to explore whether these associations differ between adults and children. METHODS: Serum 25-hydroxyvitamin D levels, serum LL-37, and clinical features were analyzed in a total of 72 Korean patients with AD (39 adults and 33 children) and 140 healthy control subjects (70 adults and 70 children). RESULTS: Serum 25-hydroxyvitamin D levels were significantly reduced in children with AD (15.06+/-4.64 ng/ml) compared with normal children in the control group (16.25+/-6.60 ng/ml) (p=0.036). Significant inverse correlations were found between BMI and 25-hydroxyvitamin D level (r=-0.315, p=0.007) and between the SCORAD score and serum LL-37 level (r=-0.3, p=0.011) in the total AD patients. CONCLUSION: The results showed that serum vitamin D levels were lower in children with AD than in healthy children; however, the same relation was not observed between adults with AD and healthy adults. Serum 25-hydroxyvitamin D concentration was not significantly correlated with AD severity or serum LL-37 levels in our study population.
