Hepatoprotective Effect Of “Antomen” Preparation On CCL4 Induced Hepatic Damage In Rats
- VernacularTitle:Туршилтын Амьтанд Үүсгэсэн Элэгний Хурц Үрэвслийн Эмгэг Загварт “Антомен” Бэлдмэлийн Үзүүлэх Нөлөө
- Author:
Uranbaigali N
1
;
Ariunaa Z
1
;
Chimedragchaa Ch
1
Author Information
- Publication Type:Journal Article
- Keywords: Loniceraaltaica pall; mentha arvensis; ccl4; hepatitis
- From: Journal of Oriental Medicine 2015;9(2):71-74
- CountryMongolia
- Language:Mongolian
- Abstract: Background: In the world the second out of top 5 diseases is gastroentorogical diseases, particularly hepatocholecystic diseases. LoniceraaltaicaPall, Menthaarvensis are contained in “Antomen” and were used in traditional medicine hepatocholecystic inflamations, oedema, gastric diseases. Objective: To study Antomen’s effect on rats with acute hepatic inflamation. Methods: 40 wistar rats weighing 180-220 g were divided into 4 groups: healthy, control, with standard treatment and antomen’s treatment. Group1 rats were fed with normal standard diet for a week.Group 2 rats (control rats were injected into abdomen with CCL40.8 mg/kg together with olive oil with dosage of 1:1. Control rats were given orally 0.9%NaCl with dosage of 0.8 mg/kg). Group 3 ( rats were injected into abdomen with CCL40.8 mg/kg together with olive oil with dosage of 1:1. Group 3 rats were given orally Carsil with dosage of 40 mg/kg). The last group (rats were injected into abdomen with CCL40.8 mg/kg together with olive oil with dosage of 1:1. Group 4 rats were given orally antomen 200 mg/kg) The experiment continued for a week and on eighth day GPT, GOT and histopathological tests were done. Results:From the result of the study it was determined the preparation has no toxicity. There were no any differences observed in movements, appetite, and color of skin in mise. Group 4 rats were compared with control rats and indications such as GPT- 25.9%, GOT-38%, alkaline phosphatase-22,1% were decreased. Conclution: It can be clearly shows that antomen preparation has hepatoprotective effect.
