Effect Of Jonsh-5 On Experimental Closed Fracture In Rats
- Author:
Ariunjargal N
1
;
Seesregdorj S
1
;
Uuganbayar B
2
;
Gereltuya B
1
;
Barkhuu D
1
Author Information
1. School of Traditional Medicine, Health Sciences University of Mongolia
2. School of Traditional Medicine, Health Sciences University of Mongoliaa Public
- Publication Type:Journal Article
- Keywords:
Jonsh-5;
bone healing;
alkaline phosphatase
- From:
Journal of Oriental Medicine
2012;3(2):21-21
- CountryMongolia
- Language:English
-
Abstract:
Jonsh-5 is composed of 5 components including calcite, Cardius
crispus, Forsythia suspense, Terminalia Chebula, and Inula
helenium.
Aim of this study is to examine the effect of traditional drug
Jonsh-5 on experimental femur fracture in rats. Jonsh-5 was
given to rats for 28 days. Calcium D3-Nycomed (2.5 g/kg) was
used for comparison. 2, 14, and 28 days after fracture, serum
levels of alkaline phosphatase were determined and fracture
healing processes were evaluated by X-ray.
Serum level of alkaline phosphatase was 197 u/l before fracture.
After 7 days of fracture, alkaline phosphatase level was
significantly increased by Jonsh-5 (728 u/l) and there were no
statistical differences observed in rats with no treatment (control)
and Calcium D3-Nycomed-treated animals. Similar patterns
were observed 14 and 21 days after fracture.
X-ray images showed that healing process of the bone was
significantly increased by Jonsh-5 compare to control and
Calcium D3-Nycomed treatment.
Jonsh-5 may promote bone healing in rat model of fracture.
