Prevalence of Respiratory Viral Infections in Korean Adult Asthmatics With Acute Exacerbations: Comparison With Those With Stable State.
10.4168/aair.2017.9.6.491
- Author:
Ki Hyun SEO
1
;
Da Jeong BAE
;
Ji Na KIM
;
Ho Sung LEE
;
Yong Hoon KIM
;
Jong Sook PARK
;
Myung Shin KIM
;
Hun Soo CHANG
;
Ji Hye SON
;
Dong Gyu BAEK
;
Jun Suk LEE
;
Choon Sik PARK
Author Information
1. Division of Allergy and Respiratory Disease, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
Asthma;
virus;
exacerbation;
season;
sputum
- MeSH:
Adenoviridae;
Adult*;
Asthma;
Humans;
Influenza, Human;
Metapneumovirus;
Orthomyxoviridae;
Paramyxoviridae Infections;
Prevalence*;
Respiratory Syncytial Viruses;
Respiratory System;
Rhinovirus;
RNA, Viral;
Seasons;
Sputum
- From:Allergy, Asthma & Immunology Research
2017;9(6):491-498
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Viral infections are involved in ~50% of exacerbations among Caucasian adult asthmatics. However, there have been few reports on the causative virus of exacerbations in Korean adult asthmatics. Thus, we compared frequencies and types of viruses between lower respiratory tract illnesses (LRTIs) with exacerbations (exacerbated LRTIs) and those without exacerbations (stable LRTIs) to evaluate contribution of respiratory viruses to exacerbations. METHODS: Viral RNA was extracted from sputum using the Viral Gene-spin™ Kit. Reverse transcription-polymerase chain reaction (RT-PCR) was performed to detect adenovirus (ADV), metapneumovirus (MPV), parainfluenza virus (PIV) 1/2/3, influenza virus (IFV) A, IFV B, respiratory syncytial virus (RSV) A/B, and rhinovirus (RV) A. RESULTS: Among the 259 patients, 210 underwent a single sputum examination, and the remaining 49 underwent 2 to 4 sputum examinations. Virus was detected in 68 of the 259 exacerbated episodes and in 11 of the 64 stable episodes. Among the exacerbated episodes, RV was the most frequently detected virus, followed by influenza A, parainfluenza, RSV A/B, and ADV. Among the 11 stable episodes, RV was most frequently detected. Detection rates of these viruses did not differ between the 2 groups (P>0.05). Thirty-five patients underwent the virus examination at 2 episodes of exacerbation, while 14 patients underwent at each time of exacerbated and stable episodes. Virus detection rate at the second examination was significantly higher in cases with 2 exacerbation episodes than in those with initial exacerbation and sequential stable episodes (P=0.003). A seasonal pattern was noted in the detection rates of RV (September to December), IFV (January to April), PIV (May to September), and RSV A/B (September to April). CONCLUSIONS: Respiratory viruses were identified in approximately 20% of LRTI irrespective of the presence of asthma exacerbation. RV and IFV A/B were most frequently detected. A group of patients experienced frequent viral infections followed by asthma exacerbations.
