Effect of Overexpression of Glucose-Regulated Protein 78 and Bcl-2 on Recurrence and Survival in Patients With Ureter Tumors.
10.4111/kju.2013.54.10.671
- Author:
Chang Hyun PARK
1
;
Mi Sun CHOI
;
Ji Yong HA
;
Byung Hoon KIM
;
Choal Hee PARK
;
Chun Il KIM
Author Information
1. Department of Urology, Keimyung University School of Medicine, Daegu, Korea. cikim@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Bcl-2;
GRP78;
Urothelial cell carcinoma
- MeSH:
Follow-Up Studies;
Humans;
Multivariate Analysis;
Prognosis;
Recurrence;
Risk Factors;
Survival Rate;
Ureter;
Urinary Bladder
- From:Korean Journal of Urology
2013;54(10):671-676
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The utility of the expression of glucose-regulated protein 78 (GRP78) in the evaluation of prognosis depends on the type of tumor. Hence, we aimed to examine the impact of expression of GRP78 and Bcl-2, which are used in the existing prognostic evaluation of ureter tumors, in the evaluation of recurrence and survival rates of ureter tumors. MATERIALS AND METHODS: In 53 patients who had undergone radical nephroureterectomy for a ureter tumor from March 2002 to March 2012, age, sex, T stage, nuclear grade, bladder recurrence, and survival rate were analyzed at the time of the patient's surgery depending on the extent of immunohistochemical expression of GRP78 and Bcl-2. RESULTS: GRP78 was overexpressed in 25 patients (47.2%). When GRP78 was overexpressed, there was a high T stage (p=0.001) and nuclear grade (p=0.007) and a lot of bladder recurrence (40.0%, p=0.034). Bcl-2 was overexpressed in 16 patients (30.1%), and there were no significant associations with any risk factors (p>0.05, respectively). In the multivariate analysis regarding bladder recurrence, the recurrence rate was higher with higher pT stage (p=0.048) and when GRP78 (p=0.033) was overexpressed. In the Kaplan-Meier survival analysis, although the survival rate was significantly lower in the group in which GRP78 was overexpressed (p=0.03), there was no correlation between Bcl-2 overexpression and survival rate (p=0.07). CONCLUSIONS: Patients with ureter tumors who had overexpression of GRP78 had a high T stage and nuclear grade, a lot of bladder recurrence, and a low survival rate. Therefore, if GRP78 is overexpressed in ureter tumor patients, active postoperative follow-up should be carried out.
