Monocarboxylate Transporter 4 Expression in Thyroid Cancer
10.11106/ijt.2024.17.2.272
- Author:
Chae A KIM
1
;
Jungmin YOO
;
Woo Kyung LEE
;
Dong Eun SONG
;
Won Gu KIM
;
Min Ji JEON
Author Information
1. Divsion of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- Publication Type:ORIGINAL ARTICLES
- From:International Journal of Thyroidology
2024;17(2):272-276
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background and Objectives:Monocarboxylate transporter 4 (MCT4) transmembrane proteins are encoded by SLC16A3 and control lactate metabolism to promote tumor growth.
Materials and Methods:Gene expression of SLC16A3 encoding MCT4 was analyzed in the database of Gene Expression Omnibus. Protein expression of MCT4 was evaluated using immunohistochemical staining in 138 papillary thyroid carcinomas (PTCs) and 21 anaplastic thyroid carcinomas (ATCs).
Results:The mRNA expression of SLC16A3 was significantly higher in ATCs compared with PTCs and normal thyroid tissue (p＜0.01, and p＜0.001, respectively). Normal thyroid tissue did not express MCT4 in immunohistochemical staining compared with ATC that was 100% positive for MCT4 protein expression. The MCT4 expression in ATCs was significantly enhanced compared with that in PTC (p＜0.001).
Conclusion:MCT4 expression is associated with de-differentiation and might be helpful as a biomarker and therapeutic target for thyroid cancer.
